The Independent Standard for Exosomes/EVs.
Our purpose: establish the standard for Exosomes/EVs, dissipate the confusion in the field, and accelerate the path to Exosomes/EVs approval in medicine.
Verification. Certification. Trust.
The independent international authority that tests, audits, and verifies what is actually in the vial, so Exosomes/EVs products become verifiable, scalable, and trusted.
SAFE✓™ certifies manufacturing processes. For individual samples, SAFE✓™ provides an independent Certificate of Analysis. Two services. One independent standard.
How it works: every analytical result submitted by our reference laboratory network is designed to enter a Trusted Execution Environment (TEE), a hardware-secured enclave that even SAFE✓™ personnel cannot access, and then to be cryptographically attested and written to an immutable blockchain. Verification is mathematical, not institutional. You will not need to trust SAFE✓™. You will be able to verify it yourself.
Nobody is checking what's in the vial.
Billions of dollars flow into Exosomes/EVs therapeutics, regenerative medicine, diagnostics, longevity, and aesthetics. Yet products reach patients with zero independent verification of identity, purity, potency, or biological activity. There is no food-safety equivalent for Exosomes/EVs. SAFE✓™ closes that gap.
No independent verification
Manufacturers self-report their own quality data. No outside authority confirms what a product actually contains before it reaches a patient.
No regulatory clarity
Exosomes/EVs products run ahead of the approval pipeline across therapeutics, regenerative medicine, and cosmetics. The rules have not caught up with the field. IRB and IND support →
No reproducibility standard
Batch-to-batch consistency is the unsolved technical problem blocking clinical trials, institutional investment, and industry scale.
Four Pillars. One Standard.
Four integrated services, all under one roof. Each is stronger because the others exist, and together they form one standard.
Consulting & Education
Strategy, SOPs, source selection, lab design, production optimization, and training, from first principles to production.
Explore services →Testing & Verification
NTA, TEM, Biogenesis Markers, and Purity form the standard verification package, source-agnostic across human, plant, and all origins. Potency, functional testing, and Omics are available at extra charge. Every result is designed to be TEE-attested and blockchain-recorded.
Explore services →Process Auditing
In-person, on-site GMP and SOP evaluation against international EV characterization standards. Audit data is designed to be processed encrypted, so compliance can be confirmed without any auditor accessing proprietary process data. Your IP is protected by design.
Explore services →Manufacturing Certification
An in-person audit of the manufacturing process, repeated across the year. The first audit earns the teal seal, certification in process; three audits across the year earn the gold mark, renewed annually and designed to be blockchain-recorded.
How it works →The teal seal and the gold mark.
Verified
The Teal Seal marks a manufacturing process currently in certification, earned once the first audit confirms the lab is properly set up and initial testing confirms the presence of exosomes.
Certified
The Gold Mark certifies a fully validated manufacturing process, earned after three rounds of audit and Teal Seal testing across the year.
Independent Verification for Cosmetic Exosomes/EVs
No independent body verifies what is actually inside a cosmetic Exosomes/EVs product before it reaches the shelf. Brands self-report; consumers just trust the label. SAFE✓™ closes that gap. We independently verify what is actually inside your product, so you can sell it with confidence and with the science behind it. It is available to any cosmetic brand.
Source-agnostic: human-derived, plant-derived, botanical, every origin, one standard
Cosmetic-grade standards, built by scientists with real formulation experience
Dedicated cosmetic reference laboratory in France, agreement being finalized
A dedicated cosmetic Exosomes/EVs verification, not pharmaceutical rules misapplied
Led by cosmetic EV experts
Led by the Scientists Who Have Done the Work
Dr. Carla Mazzeo
Founder & CEO, SAFE✓™Has personally formulated and compared commercial cosmetic EV products; she knows the quality gap in this category from the inside.
Dr. Raphaël Coatmeur
SAFE✓™ FranceTests cutaneous penetration, stability, and efficacy on human skin models; the functional proof behind every cosmetic EV claim.
A SAFE✓™ Certificate of Analysis shows your customers that an independent lab has tested a sample of your product, with a result designed so anyone can check it. That is what it means to put the science behind the label.
Verification designed so your customers can check for themselves.
Whether you make Exosomes/EVs products, administer them, or are building toward them, we are here to help you prove your quality and stand behind the science.